Agammaglobulinemia

ISBN: 9783319372495

$139.00 $118.15

This book provides an updated overview of agammaglobulinemia, a rare form of primary immunodeficiency which is considered the prototype of the congenital humoral defects, and which is characterized by the absence of peripheral B cells and very low serum immunoglobulin levels. The book opens by discussing the highly orchestrated early B cell development in the bone marrow and the genes involved based on both human and animal models. The pathogenesis and clinical presentation of X-linked agammaglobulinemia, caused by mutations in the BTK (Bruton’s tyrosine kinase) gene, are then presented in detail, followed by descriptions of the clinical manifestations and molecular basis of the less frequent autosomal recessive and autosomal dominant forms of agammaglobulinemia.  Patients’ management in terms of respiratory complications, gammaglobulin replacement therapy and the potential value of novel experimental therapeutic strategies are  discussed. The book’s closing chapters offer a comprehensive and updated description of mutations in the BTK gene, and the expression and function of BTK in cells other than B cells.

Categories: ,
Title:
Agammaglobulinemia
ISBN-13:
9783319372495
Author:
Publisher:
Springer International Publishing
Published Date:
20160823
Edition:
1
Binding
Paperback / softback
Pages:
119
Language:
English
Product Dim.:
9.25 H x 6.10 W (inches)

Special Offers and Promotions

Our print to order bookstore saves you money. There are currently no special offers for Agammaglobulinemia

Editorial Reviews

Thank you for selecting our online bookstore. Currently, there are no editorial book reviews for Agammaglobulinemia

About Pubgraphics Direct

PGDirect is an online bookstore that has embraced the concept of direct to consumer selling for self-published books, softcover and hardcover books, specialty books, children's books, hard to find books, college textbooks, print on demand books and more.

Your Cart


Fatal error: Allowed memory size of 536870912 bytes exhausted (tried to allocate 32 bytes) in /home/pgdirect/public_html/wp-includes/wp-db.php on line 1972