- Interleukin-17 is a key cytokine in first-line defence of the skin
- Kilian Eyerich
- SÃ¼dwestdeutscher Verlag fÃ¼r Hochschulschriften
- Published Date:
- Paperback / softback
- Product Dim.:
- 8.66 H x 5.91 W (inches)
Interleukin-17 is a key cytokine in first-line defence of the skin
by Kilian Eyerich
Communication between cells as a prerequisite for life of multicellular organisms is achieved mostly by solvent mediators like hormons, neurotransmitters, cytokines and chemokines. Increasing evidence suggests that a class of cytokines exists that signals from immune cells specifically towards epithelial cells. The most prominent member of these “”tissue-signaling cytokines”” is Interleukin-17 (IL-17). This book illustrates IL-17 is essential to protect the human organism at its skin surface against invading microorganisms. Cellular sources of IL-17 and trigger factors of IL-17 secretion in the skin are defined. Finally, this book identifies two human diseases associated with chronic infections of the skin that are at least partially caused by a disturbed IL-17 pathway – the orphan syndrome “”chronic mucocutaneous candidiasis”” and the very common inflammatory skin disease “”atopic dermatitis/ eczema””.
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