The immune phenotype of mice deficient for Ly49Q

ISBN: 9783845472300

$53.07 $45.11

Plasmacytoid dendritic cells are members of the innate immune system and are particularly important in anti-viral immunity since they are the most potent producers of type I interferons. This book describes the phenotype of knockout mice for Ly49Q, a cell surface receptor expressed on pDCs. In vivo, knockout mice with PGK-Neomycin insertion control early murine cytomegalovirus infection better, but no difference could be detected in mice with recombined LoxP sites. Thus, we observed a differential immune response dependent on the gene knockout strategy. In mice with PGK-Neomycin insertion, we found enhanced hematopoiesis of some populations of the myeloid lineage and lower activation of pDCs following treatment with particular Toll-like receptor ligands, which translates into diminished T cell stimulatory capacity. This suggests a role for Ly49Q in regulating hematopoiesis and pDC activation potential.

Categories:
Title:
The immune phenotype of mice deficient for Ly49Q
ISBN-10:
3845472308
ISBN-13:
9783845472300
Author:
Marie-Line Goulet
Publisher:
LAP LAMBERT Academic Publishing
Published Date:
20110907
Edition:
1
Binding
Paperback / softback
Pages:
120
Language:
English
Product Dim.:
8.66 H x 5.91 W (inches)

Marie-Line Goulet

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