- The immune phenotype of mice deficient for Ly49Q
- Marie-Line Goulet
- LAP LAMBERT Academic Publishing
- Published Date:
- Paperback / softback
- Product Dim.:
- 8.66 H x 5.91 W (inches)
The immune phenotype of mice deficient for Ly49Q
by Marie-Line Goulet
Plasmacytoid dendritic cells are members of the innate immune system and are particularly important in anti-viral immunity since they are the most potent producers of type I interferons. This book describes the phenotype of knockout mice for Ly49Q, a cell surface receptor expressed on pDCs. In vivo, knockout mice with PGK-Neomycin insertion control early murine cytomegalovirus infection better, but no difference could be detected in mice with recombined LoxP sites. Thus, we observed a differential immune response dependent on the gene knockout strategy. In mice with PGK-Neomycin insertion, we found enhanced hematopoiesis of some populations of the myeloid lineage and lower activation of pDCs following treatment with particular Toll-like receptor ligands, which translates into diminished T cell stimulatory capacity. This suggests a role for Ly49Q in regulating hematopoiesis and pDC activation potential.
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